What is tamoxifen?
Tamoxifen (Nolvadex) is a drug that reduces and/or stops the effects of estrogen (a female hormone) in the body. It was developed over 20 years ago and has been used to treat both advanced and early stage breast cancer.
Tamoxifen is taken by mouth in tablet form and is usually prescribed as a single daily dose.
How is tamoxifen used for breast cancer treatment?
As a breast cancer therapy, tamoxifen works against the effects of estrogen, which has been shown to promote the growth of breast cancer cells. It is often called an "anti-estrogen."
- As a treatment for advanced breast cancer, the drug slows or stops the growth of cancer cells that are already present in the body.
- As adjuvant therapy for early breast cancer, tamoxifen has been shown to help reduce the recurrence and development of breast cancer. Research has shown that when tamoxifen is used as adjuvant therapy for early stage breast cancer, it not only reduces the recurrence of the original cancer but also reduces the development of new cancers in the opposite breast. Based on these findings, the National Cancer Institute (NCI) sponsored a large clinical trial to determine whether tamoxifen can prevent breast cancer in healthy women who have an increased risk of developing the disease.
- Tamoxifen is only effective in women whose tumors contain receptors for estrogen or progesterone.
Additional benefits of tamoxifen:
While tamoxifen acts against the effects of estrogen in breast tissue, it acts like estrogen in other body systems. According to the National Cancer Institute, women who take tamoxifen may share some of the beneficial effects of menopausal estrogen replacement therapy, such as a lowering of blood cholesterol and a slowing of bone loss (osteoporosis).
What are the possible side effects of tamoxifen?
Women considering taking tamoxifen should consult their physician. Different women experience side effects differently. Some of the more common side effects may include: hot flashes and sweats, as well as an increase in vaginal secretions.
- weight gain
- vaginal discharge
- irregular menstrual cycles
- irritation of skin around the vagina
Less common side effects may include:
- blood clots
- uterine cancer
Some physicians and researchers caution, however, that tamoxifen therapy may not be appropriate for all women who are at increased risk for breast cancer. Consult your physician for more information regarding your individual case.
Medications recently approved by the US Food and Drug Administration (FDA), called aromatase inhibitors, are used to prevent the recurrence of breast cancer in postmenopausal women. These drugs, such as anastrozole (Arimidex®), letrozole (Femara®), and exemestane (Aromasin®), prevent estrogen production. Anastrozole is effective only in women who have not had previous hormonal treatment for breast cancer. Letrozole is effective in women who have previously been treated with tamoxifen. Possible side effects of these drugs include osteoporosis or bone fractures.
Another new drug for recurrent breast cancer is fulvestrant (Faslodex®). Also approved by the FDA, this drug eliminates the estrogen receptor rather than blocking it, as is the case with tamoxifen, letrozole, or anastrozole. This drug is used following previous antiestrogen therapy. Side effects for fulvestrant include hot flashes, mild nausea, and fatigue.