What is grading of prostate cancer?
Another step in the diagnostic process is grading the cancer cells - taking
a measurement of how fast the tumor is likely to grow and spread. Grading
is done in the laboratory with cells taken from the prostate gland during
biopsy. The cancer cells are measured by how closely they look like normal
cells.
What is the Gleason System for grading cancer?
According to the National Cancer Institute, one way of grading prostate
cancer is the Gleason System. This grading system is based on a number
range from 1 to 5. The lower the number, the lower the grade, and the
slower the cancer is growing. High grade tumors (4 and 5) grow more quickly than low grade tumors (1 and 2),
and are more likely to spread to other parts of the body.
The Gleason Score represents the sum of the two most common grades observed by the pathologist on a specimen (e.g. Gleason Score = 7 could be 3 + 4 or 4 + 3). The first number is the most frequent grade seen.